Medoodle - the international medical network and community

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Welcome to Medoodle

The international medical community and professional network

...based on the popular Radiology community Radiolopolis...

The All-Around-Medicine Community

The purpose of this medical community is to create a possibility, where most of the needs of physicians, residents, medicals students, physician assistants, nurses, technologists and industry can be melted within one central medical network. It is based on a "taking and giving" principle, where you share your knowledge and others do the same.

Some features:

  • Share cases and your knowledge
  • Ask professionals for their opinion - in public or in private
  • Find people with similar interests, create new connections and expand your professional network
  • Discuss medical topics in dedicated forums - from residency to practice
  • Prepare for the USMLE / medical baords
  • Find tutorials and eLearning material
  • Share your images, videos, teaching files and lectures
  • Simplify your research and find partners worldwide
  • Create or join research and study groups
  • General and medical specific search engines
  • Read medical news from multiple subspecialties
  • Publishing case reports (cooperation with the JRCR)
  • Helpful tools for your daily work (calculators, case tracker, clinical, research tools, etc.)
  • ...and much more...
The best: IT'S FREE!

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Recent developments in computer assisted rehabilitation environments
Computer Assisted Rehabilitation Environment (CAREN) is a system that integrates a training platform (motion base), a virtual environment, a sensor system (motion capture) and D-flow software. It is useful for both diagnostic and therapeutic use. The human gait pattern can be impaired due to disease, trauma or natural decline. Gait analysis is a useful tool to identify impaired gait patterns. Traditional gait analysis is a very time consuming process and therefore only used in exceptional cases. With new systems a quick and extensive analysis is possible and provides useful tools for therapeutic purposes. The range of systems will be described in this paper, highlighting both their diagnostic use and the therapeutic possibilities. Because wounded warriors often have an impaired gait due to...

Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model
Conclusions: Overall, this study demonstrates that the human microtissue model utilised herein is an excellent candidate for replacement of traditional in vitro single cell hepatic models and further progression of liver nanotoxicology.
(Source: BioMed Central)

Gelatin-chondroitin-6-sulfate-hyaluronic acid scaffold seeded with vascular endothelial growth factor 165 modified hair follicle stem cells as a three-dimensional skin substitute
IntroductionIn the field of skin tissue engineering, gelatin-chondroitin-6-sulfate-hyaluronic acid (Gel-C6S-HA) stents are a suitable bio skin substitute. The purpose was to investigate the effect of genetically-modified hair follicle stem cells (HFSCs), combined with Gel-C6S-HA scaffolds, on the vascularization of tissue-engineered skin. Methods: Three-dimensional (3D) Gel-C6S-HA scaffolds were prepared by freeze-drying. Vascular endothelial growth factor (VEGF) 165 gene-modified rat HFSCs (rHFSCs) were inoculated into the scaffolds and cultured for 7 days. Two bilateral full-thickness skin defects were created on the back of 18 Sprague-Dawley rats. Rats were randomly divided into four groups: Group A, HFSCs transduced with VEGF165 seeded onto Gel-C6S-HA scaffolds; Group B, HFSCs transduc...

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The role of small RNAs in wide hybridisation and allopolyploidisation between Brassica rapa and Brassica nigra
Conclusions: The study showed that siRNAs and DNA methylation play an important role in maintaining the genome stability in the formation of an allotetraploid. The miRNAs regulate gene expression and induce the phenotype variation, which may play an important role in the occurrence of heterosis in the allotetraploid. The findings of this study may provide new information for elucidating that the allotetraploids have a growth advantage over the parents and the allodiploids.
(Source: BioMed Central)

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Neofunctionalization of a duplicate hatching enzyme gene during the evolution of teleost fishes
Conclusions: We infer the process of neofunctionalization of the clade II enzyme after duplication of the gene. The ancestral clade II gene gained N-ZPd cleavage activity in the common ancestral lineage of the Euteleostei and Otocephala. Subsequently, acquisition of cleavage activity at the mid-ZPd site and loss of cleavage activity in the N-terminal region occurred during the evolution of Euteleostei, but not of Otocephala. The clade II enzyme provides an example of the development of a neofunctional gene for which the substrate, the egg envelope protein, has adapted to a gradual change in the specificity of the corresponding enzyme.
(Source: BioMed Central)

Transcriptomic portrait of human Mesenchymal Stromal/Stem cells isolated from bone marrow and placenta
Conclusions: The results present a transcriptomic portrait of the human MSCs isolated from bone marrow and placenta. The data are released as a cell-specific resource, providing a comprehensive expression footprint of the MSCs useful to better understand their cellular and molecular biology and for further investigations on the isolation and biomedical use of these multipotent cells.
(Source: BioMed Central)

Nurses' self‐reported medication competence in relation to their pharmacovigilant activities in clinical practice
ConclusionDedicated university courses improved nurses' self‐reported competence in pharmacovigilance but did not increase the number of related activities. Education per se seems to be not sufficient to generate pharmacovigilant activities among nurses.
(Source: Journal of Evaluation in Clinical Practice)

From caveat emptor to caveat venditor: time to stop the influence of money on practice guideline development

(Source: Journal of Evaluation in Clinical Practice)

[Articles] The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial
Our findings support the safety profile of nitrous oxide use in major non-cardiac surgery. Nitrous oxide did not increase the risk of death and cardiovascular complications or surgical-site infection, the emetogenic effect of nitrous oxide can be controlled with antiemetic prophylaxis, and a desired effect of reduced volatile agent use was shown.
(Source: LANCET)

Determinants of perceived quality of obstetric care in rural Tanzania: a cross-sectional study
Conclusions: A woman's expectations, and prior and current experiences influence her perception of the quality of care she received. Health facility characteristics did not influence ratings of overall quality. Focusing on improving the process rather than inputs of service delivery during ANC visits and delivery may increase perceived quality of delivery care in low-resource settings.Trial registration: ISRCTN17107760
(Source: BMC Health Services Research)

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